CDK7 Antikörper (C-Term)

Produktnummer ABIN452138

Der Maus Monoklonal Anti-CDK7 Antikörper wurde für WB, IP, IF, IHC (fro) und FACS validiert. Er ist geeignet, CDK7 in Proben von Human zu detektieren.

Kurzübersicht für CDK7 Antikörper (C-Term) (ABIN452138)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CDK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Klon: MO-1-1

Produktdetails anti-CDK7 Antikörper

Bindungsspezifität: C-Term

Spezifität: Mo-1.1 recognizes the key cell cycle regulator cdk7, which is essential to activate the cdk2 kinase in G1 phase and the cdc2 kinase in G2/M phase.

Produktmerkmale: Synonyms: CAK1, P39 Mo15, STK1, CDK-activating kinase, Cell division protein kinase 7, TFIIH basaltranscription factor complex kinase subunit, 39 kDa protein kinase

Aufreinigung: Protein A affinity chromatography

Immunogen: Recombinant C-terminal 221 aa fragment of human wild-type cdk7/CAK (cyclin activatingkinase)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry of frozen sections: 1/10 - 1/20, 1h at RT. Immunofluorescence. Immunoprecipitation of active kinase complex. Cell sorting (FACS analysis). Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in 1 mL dist. water (final solution contains 0.09 % NaN3, 0.5 % BSA in PBS buffer, pH 7.4).

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Andere Bezeichnung: CDK7

Hintergrund: Cdk7 is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. Cdk7 forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.Synonyms: 39 kDa protein kinase, CAK1, CDK-activating kinase, Cell division protein kinase 7, P39 Mo15, STK1, TFIIH basal transcription factor complex kinase subunit

Gen-ID: 1022

UniProt: P50613

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase